| 2021-09-04 14:00:00September 4, 2021 | Newent vs North Petherton 1st | 44 - 22 | Tribute South West 1 West | 2021-22 | Newent | Recap | - |
| 2021-09-11 14:00:00September 11, 2021 | Wellington vs North Petherton 1st | 26 - 20 | Tribute South West 1 West | 2021-22 | Wellington | Recap | - |
| 2021-09-18 14:00:00September 18, 2021 | North Petherton 1st vs Old Patesians | 48 - 14 | Tribute South West 1 West | 2021-22 | North Petherton | Recap | - |
| 2021-09-25 14:00:00September 25, 2021 | Sidmouth vs North Petherton 1st | 21 - 15 | Tribute South West 1 West | 2021-22 | Sidmouth | Recap | - |
| 2021-10-02 14:00:00October 2, 2021 | North Petherton 1st vs St Austell | 17 - 40 | Tribute South West 1 West | 2021-22 | North Petherton | Recap | - |
| 2021-10-23 14:00:00October 23, 2021 | North Petherton 1st vs Thornbury | 33 - 26 | Tribute South West 1 West | 2021-22 | North Petherton | Recap | - |
| 2021-10-29 19:30:47October 29, 2021 | North Petherton vs Bridgwater & Albion | 10 - 6 | Tribute South West 1 West | 2021-22 | Bridgwater & Albion | Recap | - |
| 2021-11-06 14:30:00November 6, 2021 | North Petherton 1st vs Chew Valley | 31 - 46 | Tribute South West 1 West | 2021-22 | North Petherton | Recap | Saturday |
| 2021-11-20 14:30:00November 20, 2021 | Crediton vs North Petherton 1st | 14:30:002:30 pm | Tribute South West 1 West | 2021-22 | Crediton | Recap | Saturday |
| 2021-11-27 14:30:00November 27, 2021 | North Petherton 1st vs Devonport Services | 14:30:002:30 pm | Tribute South West 1 West | 2021-22 | North Petherton | Recap | Saturday |
| 2021-12-04 14:30:00December 4, 2021 | Keynsham vs North Petherton 1st | 14:30:002:30 pm | Tribute South West 1 West | 2021-22 | Keynsham | Recap | Saturday |
| 2021-12-11 14:30:00December 11, 2021 | North Petherton 1st vs Lydney | 14:30:002:30 pm | Tribute South West 1 West | 2021-22 | North Petherton | Recap | Saturday |
| 2021-12-18 14:30:00December 18, 2021 | North Petherton 1st vs Wellington | 14:30:002:30 pm | Tribute South West 1 West | 2021-22 | North Petherton | Recap | Saturday |
| 2022-01-08 14:30:00January 8, 2022 | Old Patesians vs North Petherton 1st | 14:30:002:30 pm | Tribute South West 1 West | 2021-22 | Old Patesians | Recap | Saturday |
| 2022-01-14 19:30:00January 14, 2022 | North Petherton 1st vs Sidmouth | 19:30:007:30 pm | Tribute South West 1 West | 2021-22 | North Petherton | Recap | Friday |
| 2022-01-22 14:30:00January 22, 2022 | St Austell vs North Petherton 1st | 14:30:002:30 pm | Tribute South West 1 West | 2021-22 | St Austell | Recap | Saturday |
| 2022-02-12 14:30:00February 12, 2022 | Thornbury vs North Petherton 1st | 14:30:002:30 pm | Tribute South West 1 West | 2021-22 | Thornbury | Recap | Saturday |
| 2022-02-18 19:30:00February 18, 2022 | North Petherton 1st vs Bridgwater & Albion | 19:30:00Cancelled | Tribute South West 1 West | 2021-22 | North Petherton | Recap | Friday |
| 2022-03-05 14:30:00March 5, 2022 | Chew Valley vs North Petherton 1st | 14:30:002:30 pm | Tribute South West 1 West | 2021-22 | Chew Valley | Recap | Saturday |
| 2022-03-12 14:30:00March 12, 2022 | North Petherton 1st vs Crediton | 14:30:002:30 pm | Tribute South West 1 West | 2021-22 | North Petherton | Recap | Saturday |
| 2022-03-26 14:30:00March 26, 2022 | Devonport Services vs North Petherton 1st | 14:30:002:30 pm | Tribute South West 1 West | 2021-22 | Devonport Services | Recap | Saturday |
| 2022-04-02 14:30:00April 2, 2022 | North Petherton 1st vs Keynsham | 14:30:002:30 pm | Tribute South West 1 West | 2021-22 | North Petherton | Recap | Saturday |
| 2022-04-09 14:30:00April 9, 2022 | Lydney vs North Petherton 1st | 14:30:002:30 pm | Tribute South West 1 West | 2021-22 | Lydney | Recap | Saturday |
| 2022-04-23 14:30:00April 23, 2022 | North Petherton 1st vs Newent | 14:30:002:30 pm | Tribute South West 1 West | 2021-22 | North Petherton | Recap | Saturday |
